Mechanisms underlying treatment response in psychosis (MUTRIPS)

MUTRIPS in a European Research Council funded project which aims to identify the neural mechanisms underlying antipsychotic treatment response in psychosis. The key hypothesis is that lack of adequate response to treatment, the persistence of symptoms despite optimal contemporary treatment, is characterised by a failure of prefrontal cognitive control mechanisms, specifically in modulation of feedback learning.

We are utilising structural and functional magnetic resonance imaging (MRI) both in chronic schizophrenia and in first episode psychosis. Our measures include task-related MRI, magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), and multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT).

Researchers: Sukhi Shergill, Elias Mouchlianitis, Lucy Vanes, Erica Barry, Katie Wong, Krisna Patel